In SMA mice treated with AA, EAAT1 protein and mRNA levels were upregulated compared to vehicle-treated SMA mice (p < 0.0001, Fig. 6c; p < 0.001, Fig. 6d; p = 0.023, Fig. 6e) (Supplementary Fig. 5, online resource) with a reduction of glutamate levels (p < 0.0001) (Fig. 6f), while the loss of MNs was prevented in SMA mice (p = 0.001) (Fig. 6g. The gene discussed is SLC1A3; the disease is proximal spinal muscular atrophy.