TARDBP and amyotrophic lateral sclerosis: However, it is unknown whether normal TDP-43 without prior post-translational modification or RNA-binding impairment recruited to anisosomes can interact with RNA, and has been difficult to determine through post-mortem studies whether acetylated TDP-43 anisosomes inhibit or seed TDP-43 aggregation, or whether anisosomes indeed form in human ALS and FTD [25].