Additionally, exogenous wild-type TDP-43 is incorporated into cytoplasmic TDP-43 structures in cells [33, 62–64], resembling pathological inclusions observed in ALS and FTLD-TDP that contain full-length natively-folded TDP-43 [21, 26, 27, 29, 65]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.