The activating receptor NKG2D and its ligands (MICA, ULBP3) play an important role in innate (NK, ILC1), ‘translational’ (γδ T-cells) and CD8 T-cell-mediated immune responses to tumors and in several autoimmune diseases (Frazao et al., 2019; Babic and Romagnani, 2018). The gene discussed is CD8A; the disease is autoimmune disease.