ILC1 cells are classified as a component of type 1 immunity (Shannon et al., 2021), express NKG2D, recognize conserved phosphoantigens (Nabekura and Shibuya, 2021a), and contribute to immunity against tumor cells, for example through NKG2D activation (Dadi et al., 2016). This evidence concerns the gene KLRK1 and neoplasm.