MICA and Hand-foot syndrome: We then co-cultured autologous ILC1lc with freshly organ-cultured scalp HFs from the same patient, that is under conditions where the epithelium of these HFs transiently undergo an acute stress response and overexpresses MICA (Uchida et al., 2021), to check whether these innate lymphocytes exert any HFs cytotoxicity and/or impact on the physiological immune privilege (IP) of HFs (Bertolini et al., 2020; Paus et al., 2005; Ito et al., 2004; Peters et al., 2007; Bertolini et al., 2016).