TGFB1 and Hand-foot syndrome: Immunohistology revealed that ILC1lc, just like autologous enriched CD8/NKG2D cells, induced a phenocopy of AA immunopathology in previously healthy human scalp skin in vivo, in sharp contrast to the negative control PBMCs/PHA group: HFs dystrophy, miniaturization and perifollicular lymphocytic infiltrate around anagen HFs (Figure 7B) as well as induction of HF-IP collapse (significantly increased expression of HLA-A,B,C, β2 MG, and HLA-DR of the HF epithelium, along with downregulation of the immune privilege guardians, α-MSH and TGF-β1) (Figure 7C and D).