That IL-12 and IL-18 were among the cytokines used here to facilitate ILC1lc isolation from human PBMCs is also interesting in the context of our most recent observation that local IL-12 signaling, supported by IL-18, may be involved in the early stages of AA development by stimulating IFN-γ production from resident IL-12Rß2+immune cells, eventually leading to HF-IP collapse (Edelkamp, 2021). This evidence concerns the gene IL18 and incontinentia pigmenti.