CXCL12 and Hand-foot syndrome: Day 1 HFs also show signs of mild HF dystrophy (as evidenced by increased lactate dehydrogenase [LDH] release into the medium), and express chemokines recognized for their relevance in AA pathobiology, that is CXCL10 and CXCL12 (Uchida et al., 2021; Ito et al., 2020).