MUC5AC and gallstones: Subsequently, the cholesterol level in the bile is so high that bile salts cannot dissolve it.[15] In addition to hypomotility of the gall bladder, increased prostaglandins and arachidonic acid, as well as increased secretion of calcium and mucin, promote the formation of cholesterol crystals.[12] To date, 2 approaches have been used to manage gallstones in bariatric patients: perioperative cholecystectomy and UDCA.