STC2 and neuroblastoma: In both humans and mice, STC2 is made up of 4 exons that span 13kb of DNA.[31] Upregulation of STC2 in N2a mice neuroblastoma cell lines after being subjected to thapsigargin- and tunicamycin-stimulated estrogen receptor stress was the first piece of evidence for STC2’s cytoprotective role, presented by Thinakaran et al.[28] An upregulation of STC2 was also observed following hypoxia and oxidative stress mediated by H2O2.