GFRA3 and chronic pancreatitis: Its signal transduction mainly regulates intracellular signal transduction by combining with the co-receptor GFR α 3-RET to regulate intracellular signal transduction, thus affecting neural system development and cell homeostasis.[39] Ceyhan et al[22] showed that in chronic pancreatitis, GFRalpha3 and ARTN exhibited a substantial overexpression and were sited in neural ganglia, Schwann cells, and smooth muscle cells of arteries.