APOA1 and autoimmune thyroid disease: The imbalance between estrogen and progesterone levels may be responsible for the frequent co-occurrence of autoimmune thyroiditis in women with PCOS.[5] Our investigation confirmed that PCOS patients are more likely than the general population to have problems with glucolipid metabolism by finding higher levels of FINS, HOMA-IR, LDL, TG, apoB, apoB/apoA1, and HCY in PCOS patients.