LPL and hypothyroidism: According to Yi Lei, Hashimoto’s thyroiditis affects normal thyroid function and produces hypothyroidism in patients, resulting in lower LDL cholesterol clearance and inhibition of lipoprotein lipase activity, ultimately leading to higher serum TC levels.[17] Patients with PCOS and autoimmune thyroid disease had considerably increased incidences of diabetes, hyperlipidemia, and cardiovascular disease, according to Chun-Wei Ho et al.