TF and Iron deficiency anemia: Human Tf is a 76-kDa glycoprotein that is mainly produced in the liver and has a half-life of approximately 8 days in serum.[1] All vertebrates have functional Tf or ovotransferrin, which has iron-binding and antibacterial properties in reptiles and birds.[2] When the tissue demand for iron increases, iron deficiency triggers the transcription of TfR1 by hypoxia-inducible factors.