TF and Tangier disease: Iron overload is a common symptom in patients with CHB, with up to 27.1% of patients having elevated Tf saturation and 48.7% having liver iron deposition.[28] Furthermore, the concentration of serum ferritin decreases after treatment with antiHBV drugs.[29] The level of serum iron in patients with positive serum HBsAg is higher than that in patients without HBsAg, regardless of the level of transaminase.[30] In patients with CHB, iron storage involves elevated serum iron and ferritin levels and continuous accumulation of iron in the liver.