Precise control of IFN responses is critically important, as misregulation of IFNs can result in immunopathogenesis and autoimmunity or exacerbate the pathogenesis of respiratory viral infections (Baechler et al, 2003; Banchereau & Pascual, 2006; Blanco‐Melo et al, 2020; Hadjadj et al, 2020; Galani et al, 2021). This evidence concerns the gene IFNA1 and Autoimmunity.