The recently discovered novel CSE inhibitor I157172 up‐regulates sirtuin 1 (SIRT1) and inhibits the phosphorylation and deacetylation of STAT3, the expression of MMP2/9, p‐Akt, and Bcl‐2, which in turn inhibits the migration and invasion of BC cell line MCF7.120. This evidence concerns the gene MMP2 and breast cancer.