3‐MST inhibited the Akt/FOXO3a/p27 and cyclin D1/CDK4/Rb/E2F1 signalling pathways by increasing the production of H2S and inhibited the proliferation, migration, and invasion of HCC cell lines HepG2 and MHCC‐LM3 by increasing the cleaved caspase‐3 and PARP levels.132. The gene discussed is AKT1; the disease is hepatocellular carcinoma.