Studies have shown that CBS is not detected in benign prostatic epithelium, while low and high levels of CBS are detected in benign hyperplasia prostate cell lines and androgen‐dependent prostate cancer cell lines (LNCaP and DU145), respectively, which seems to indicate that high expression of CBS promotes the progression of prostate cancer, while low expression of CBS is found in bone metastatic cell lines of prostate cancer PC‐3. The gene discussed is CBS; the disease is benign prostatic hyperplasia.