In HCC cell lines Hep3B and MHCC97H, CBS inhibits tumour growth by regulating apoptosis‐related proteins (cleaved Caspase‐3 and Bcl‐3) and inhibiting the transcription of paired related homeobox 2 by interleukin‐ 6 (IL‐6), which negatively regulates the expression of STAT3. This evidence concerns the gene STAT3 and hepatocellular carcinoma.