CBS and esophageal adenocarcinoma: Deletion of CBS also leads to regulation of inflammation and H2S production, particularly, through the elevation of TNF‐α and NF‐κB activity, which is accompanied by the reduction of H2S. In addition, epimutation of CBS has also been associated with CIMP in bladder urothelial carcinoma, oesophageal adenocarcinoma, head and neck squamous cell carcinoma, HCC, and uterine corpus endometrial carcinoma.15