For example, Gata4± mice have a reported CHD incidence ranging from 12 to 76% (Rajagopal et al. 2007), Nkx2-± between 5 and 50% (Winston et al. 2010), and Tbx5± between 40 and 80% (Bruneau et al. 2001). This evidence concerns the gene TBX5 and coronary artery disorder.