CRELD1 and familial atrioventricular septal defect: CRELD1, which was the top-scoring gene in VAAST 2.0 and highly ranked in all 3 gene burden tests, has been implicated in both syndromic and non-syndromic CHD (Ackerman et al. 2012; Robinson et al. 2003; Zatyka et al. 2005), specifically atrioventricular septal defects.