HLA-DRB1 and type 1 diabetes mellitus: HLA-DRB1*0801 and HLA-DQA1*0401 are in strong LD with HLA-DQB1*0402 (P = 5.2 × 10−8) and have been associated with autoimmune disease, including type 1 diabetes and systemic lupus erythematosus (27).