Likewise, transgenic expression of 4E-BP1 in male mice alleviates metabolic disorder and aging-induced obesity (Tsai et al., 2016a) while the deficiency of 4E-BP1 and 4E-BP2 accelerates mouse embryonic fibroblast senescence (Petroulakis et al., 2009). Here, EIF4EBP1 is linked to obesity due to melanocortin 4 receptor deficiency.