LATS1 and neoplasm: In general, when the pathway is turned off, a cascade of kinases (MST1/2 and LATS1/2) are dephosphorylated, followed by nuclear translocation of the dephosphorylated transcriptional coactivators YAP/TAZ, where they transcriptionally activate tumor promoting genes or repress tumor suppressive genes Zanconato et al., 2016; Xie et al., 2018).