CD8A and Miyoshi myopathy: In MM patients aged >70 years treated with lenalidomide and dexamethasone in the GEM-CLARIDEX clinical trial (NCT02575144), those with a high BM CD8+ T/Treg cell ratio showed a higher rate of early relapse in comparison with those with low values (PFS, 18 months versus not reached; P = 0.0114; Fig. 5i and Extended Data Fig. 7b).