MYC and Miyoshi myopathy: Analysis of the genomic characteristics in MM cells from the models of early and late progression revealed that MIcγ1 mice exhibited normal karyotypes without MYC translocations, while BIcγ1 mice with Trp53 deletion exhibited more abundant chromosomal abnormalities and higher TMB compared with the strains without Trp53 deletion (Fig. 3b and Supplementary Fig. 6).