Among those, the most common combinations (21/24) included anaplastic (pilocytic) astrocytomas or glioblastomas (WHO grade 3–4) assigned to DNA methylation classes of lower-grade gliomas, including PA, GG or MYB/MYBL-altered tumors (WHO grade 1–2) (Fig. 2 and Supplementary Fig. 6a). Here, MYB is linked to central nervous system cancer.