PLAGL1 and neuroepithelial neoplasm: Visualization of DNA methylation patterns by t-distributed stochastic neighbor embedding (t-SNE) (Fig. 3a and Supplementary Table 4), and subsequent class assignment by visual inspection (Supplementary Fig. 8a), allowed classification of another 229 samples, with profiles of 34 tumors (3.0%) suggestive of novel molecular classes not represented in the original reference cohort4, such as HGG of the posterior fossa and neuroepithelial tumors with PATZ1 fusions12 or PLAGL1 fusions13 (Fig. 3b,c and Supplementary Fig. 8c).