CASP3 and ovarian cancer: Additionally, Shen et al. supposed that pathways other than those associated with apoptosis or necrosis inhibited the proliferation of ovarian cancer cell lines (OVCAR-429 and PA-1), as they indicated non-significant increases in the percentage of cells undergoing necrosis, apoptosis or caspase 3 activation after 4 h of melatonin treatment at 400 to 800 μM28.