Anti-PM/Scl-75 (2 cases), anti-Mi2 (1 case), anti-(Sm/RNP/anti-chromatin +) (1 case), anti-Pl-12 + and anti-Scl100 + (1 case), and anti-HMGCR + (1 case) had more dominant myopathic features with versus skin manifestations or ILD. The gene discussed is RNPC3; the disease is interstitial lung disease.