When we performed a stratified analysis based on age (<65 vs. ≥65 years), sex, smoking status, number of OHA classes (<3 vs. ≥3), diabetes duration (<5 vs. ≥5 years), and insulin use, abdominal obesity was identified as a significant risk factor for the development of glioma in younger individuals (<65 years), men, non-smokers, diabetic patients with longer disease duration, those who are on fewer OHAs classes, and those who are not using insulin (Table 3). This evidence concerns the gene INS and central nervous system cancer.