Even after adjusting for covariates including age, sex, smoking status, alcohol consumption, household income, BMI, diabetes duration, insulin use, and number of OHAs, the WC ≥90 cm (men)/85 cm (women) groups had significantly higher risks of glioma (adjusted HR [95% CI]; 1.279 [1.053, 1.554] in the WC <95 cm (men)/90 cm (women) group; 1.317 [1.048, 1.655] in the WC <100 cm (men)/95 cm (women) group; 1.369 [1.037, 1.807] in the WC ≥100 cm (men)/95 cm (women) group) (Table 2, Fig 2b). This evidence concerns the gene INS and central nervous system cancer.