Gene set enrichment analysis (GSEA) of the gene expression profile in the infected Ifnar1fl/fl mice revealed various biological pathways associated with infection, including upregulation of genes for the type I IFN production and cellular response to type I IFNs, IFN-γ-mediated signaling and cytokine-mediated signaling pathways (Fig. 2d), consistent with findings from previous studies13,15,29. The gene discussed is IFNG; the disease is infection.