In SLE, we found many interferon related genes such as IFI27 (Interferon alpha-inducible protein 27), IFI16 (Gamma-interferon-inducible protein 16), IFI27L1 (Interferon Alpha Inducible Protein 27 like 1), IFNAR1 (Interferon alpha/beta receptor 1), IFI6 (Interferon Alpha Inducible Protein 6), IFI44 (Interferon Induced Protein 44), IFIT1-3, 5 (Interferon Induced Protein with Tetratricopeptide Repeats) which were all upregulated. The gene discussed is IFI27; the disease is systemic lupus erythematosus.