CD4 and rheumatoid arthritis: The chosen studies consisted of seven datasets for RA (4 PBMC; 2 WB; 1 CD4 T and B cells) and 7 for SLE (4 PBMC; 2 WB; and 1 CD4 T and B cells), which included 580 samples for RA (415 RA patients and 165 controls) and 508 for SLE (317 SLE patients and 191 controls) as shown in Fig 1.