WGD and chromothripsis seemed to push tumors away from the tumor–immune interaction phenotype (q values = 0.042 and 0.012, respectively; Fig. 5c); indeed, both cell division and acinar phenotypes were characterized by low immune cell infiltration (cold tumors), which may be explained by the downregulation of the interferon response pathway and B2M expression seen in WGD + MPM tumors (q value = 7.4 × 10−17; Supplementary Fig. 18a,b,e and Supplementary Tables 9 and 10). Here, B2M is linked to neoplasm.