TERT and cancer: Estimates of the timing of WGD, TERT amplification and copy-neutral LOH in the few samples (n = 6) with such events where a subclonal deconvolution was possible showed that our samples fall well within the values observed across >2,500 tumors of the Pan-Cancer Analysis of Whole Genomes Consortium46 (empirical P values = 0.16–0.79; Fig. 5d and Supplementary Fig. 21).