FAT3 and cancer: The remaining seven driver genes have, to our knowledge, not been previously reported in MPM, but they are all known cancer genes, as reported in COSMIC: FAT3, NIN, ARHGAP5, HLA-A, NCOR2, SRGAP3 and WNK2. Of note, NF2 and MYH9 (IntOGen drivers) are located within the significantly deleted chr22q region, along with TTC28—a gene frequently altered by structural variants (Figs. 3a,b and 4).