DSC2 and psoriasis: Based on transcriptomic analysis lituratures20,21, majority of the core alteration DEGs were psoriasis signature genes (genes that tend to be more specifically expressed in psoriasis than other skin diseases or play a well-known role in psoriasis) (e.g., IL36G, DEFB4A/B, S100A7A (S100A15), SERPINB3, SERPINB4, KRT16, KRT6A, DSC2, and GJB2).