TNF and psoriasis: It induces the expression of other psoriasis signature genes, such as IL36G, S100A15, DEFB4A, S100A9, CXCL8, TNIP3 (coding TNF-α-induced-protein 3 or TNFAIP3), and LCN2 (by synergy of IL-17C with TNF-α) in keratinocytes18,20.