Characterization of the functional role of hepcidin and erythroferrone in PV was undertaken in a novel knockin inducible Jak2-V617F transplant model, with induction of the phenotype by tamoxifen delayed to ensure recovery of the mouse from the toxicity of the transplant procedure, which could itself induce inflammation and perturb hepcidin.65 The gene discussed is HAMP; the disease is acquired polycythemia vera.