Janus kinases (JAKs) and signal transducer and activator of transcription proteins (STATs) modulate the intracellular signaling of key cytokines implicated in AD, such as Th2 (IL-5, IL-4, IL-13), Th17 (IL-17A, IL-17F, IL-21), Th22 (IL-22) and Th1 (IFN-γ, IL-2, TNF-β) cytokines [135]. This evidence concerns the gene IFNG and Alzheimer disease.