CD8A and neoplasm: Interactions related to lymphocyte recruitment signaling to exhibit anti-tumor effect between CD8 + T/NK and CAF(CXCR3-CXCL949, CXCR3-CCL1959) were most intensive in RBT group, while the pro-tumor state was most enhanced by interactions between Treg and CAF in NBT group (Fig. 5e).