RB1 and cancer: Importantly, we found that depleting RB in RB1-intact cancer cell lines from a range of histological origins, including the lung (A549; Supplemental Figure 1B), liver (HepG2; Supplemental Figure 1D), and breast (MCF7; Supplemental Figure 1F), also sensitized them to ferroptosis induction (Supplemental Figure 1, C, E, and G).