E2F1 and Familial prostate cancer: To determine the mechanisms underlying RB-regulated ferroptosis, putative E2F1 target genes known as ferroptosis regulators were selected from E2F1 ChIP-Seq data sets generated from prostate cancer cell lines (GEO GSE36614 and GSE67809) and from HeLa (ENCODE GSM935484) and MCF7 (ENCODE GSM935477) cell lines.