To determine the mechanisms underlying RB-regulated ferroptosis, putative E2F1 target genes known as ferroptosis regulators were selected from E2F1 ChIP-Seq data sets generated from prostate cancer cell lines (GEO GSE36614 and GSE67809) and from HeLa (ENCODE GSM935484) and MCF7 (ENCODE GSM935477) cell lines. Here, E2F1 is linked to prostate carcinoma.