It seems clear from the inferential tree that, when upfront US designates a tumor as ovarian, further MRI signal diffusion and CA125/CEA ratio are capable of nearly offsetting US error: patients with MRI signal diffusion low/absent and those with signal high but CA125/CEA ratio ≥25 had an extremely low probability (<1%) of being of non-ovarian origin. The gene discussed is MUC16; the disease is neoplasm.