Several pathways that have so far not been reported for the heart included: synaptogenesis (upregulated in the HCM LV and downregulated in the HCM LA), glioma and reelin (upregulated in the HCM LV) and stathmin 1 (upregulated in the HCM LA), as well as endocannabinoid neuronal synapse and opioid signaling (both downregulated in the HCM LA) (Fig 6A and 6B). This evidence concerns the gene RELN and central nervous system cancer.