RELN and glioma: Several pathways that have so far not been reported for the heart included: synaptogenesis (upregulated in the HCM LV and downregulated in the HCM LA), glioma and reelin (upregulated in the HCM LV) and stathmin 1 (upregulated in the HCM LA), as well as endocannabinoid neuronal synapse and opioid signaling (both downregulated in the HCM LA) (Fig 6A and 6B).