Moreover, many related functions or pathways, such as type I and type II IFN responses and parainflammation, also have higher scores in the high-risk group; they can play different roles in tumorigenesis and development, such as promoting tumor growth and proliferation and migration to metastatic sites [34], evading immunosurveillance [35] and inducing the tumor cell cycle [36]. This evidence concerns the gene IFNA1 and neoplasm.