Ectopic expression of 3 of the most consistently upregulated genes involved in xenobiotic metabolism, Gstm1, Gstm3, and Gstm5, readily caused an increase in GST activity and resistance to sotorasib in PDX-dc1 and MIA Paca-2 human tumor cells known to be sensitive to sotorasib (30) (Figure 7, E and F, and Supplemental Figure 10), indicating that the GSTM class of detoxifying enzymes can modify the response to sotorasib, resulting in its reduced antitumor activity. This evidence concerns the gene GSTM1 and neoplasm.