None of the female carriers in ORCADES are compound heterozygotes for pathogenic or likely pathogenic exonic BRCA1 alleles, for which there are multiple submitters and no conflicts in ClinVar, neither do they carry known pathogenic exonic variants in the cancer susceptibility genes APC, BRCA2, RET, PALB2, MAX, TMEM127, BMPR1A, SMAD4, TP53, MLH1, MSH2, MSH6, PMS2, MEN1, MUTYH, NF2, SDHD, SDHAF2, SDHC, SDHB, PTEN, RB1, VHL or WT1. The gene discussed is APC; the disease is cancer.