Interestingly, similar generalized overgrowth phenotypes are caused by inactivating variants in other genes that participate in epigenetic regulatory pathways mostly as epigenetic writers, including EZH2 (Weaver syndrome) (5), EED (Cohen-Gibson syndrome) (23), SUZ12 (Imagawa-Matsumoto syndrome) (24), NSD1 (Sotos syndrome) (6), and DNMT3A (Tatton-Brown-Rahman syndrome) (7). Here, NSD1 is linked to Weaver syndrome.