CDKN1C and Beckwith-Wiedemann syndrome: For example, Beckwith-Wiedemann syndrome can result from increased expression of insulin-like growth factor 2 (IGF2) (2), a paracrine growth factor, and/or from decreased expression or inactivating variants in cyclin-dependent kinase inhibitor 1c (CDKN1C) (3), which regulates cell cycle progression.