FASN and heart failure: To identify fatty acid accymulation after UA aggravated heart failure, expression analyses of lipid metabolism related genes including fatty acid synthase (Fasn), fatty acid desaturase 2 (fads2), fatty acid elongase 2 (elov2), and stearoyl-CoA desaturase (scd) were performed (Additional file 1: Fig. S3), and Fasn was increased in UA treated zebrafish heart failure model (Fig. 5a), indicating the regulatory role of UA in heart failure via dysfunction of FFA synthesis.