NPPB and hydrops fetalis: However, through the pooled analysis of six studies, Xu and colleagues demonstrated uric acid-lowering therapies did not improve ejection fraction (EF), N-terminal pro hormone B-type natriuretic peptide (NT-proBNP), as well as all-cause mortality and cardiovascular death (CVD) in HF patients, considering UA may just be a risk marker of HF [6].