Infection happens in microglia even with the high expression level of cell restrict factor SAMHD1 [Sterile alpha motif (SAM) domain and histidine–aspartate (HD) domain 1] [25], which is probably attributed to its phosphorylation by cyclin-dependent kinase 1 (CDK1), that occurs in cells cycling between G0 and G1 status [26]. The gene discussed is CDK1; the disease is infection.