ERFE and congenital dyserythropoietic anemia type 2: It was demonstrated that the pathogenesis of iron overload in iron-loading anemias, such as CDA type II (CDAII) and beta-thalassemia, is related to the over-expression of the erythroblast-derived hormone erythroferrone (ERFE)9, leading to hepcidin suppression10–12.