To further interrogate the role of BRF2 in HCC, we used the RNA Target Scan database to systemically search for microRNAs that bind to BRF2 and found that miR-409-3p can bind to the 3′ untranslated region (3′ UTR) of BRF2 (Fig. 3A). This evidence concerns the gene BRF2 and hepatocellular carcinoma.