Sequencing data and qPCR experiments as well as analysis of PD-related GEO data also demonstrated that the expression levels of the DNB core gene HSF1 and the DNB gene MAPKAPK2 correlated with the level of the neighbouring gene SERPINE1 and that these three genes may be potential biomarkers of the pathological pre-aggregation of α-Syn, while revealing that MAPKAPK2 in peripheral blood may be a potential biomarker for an early PD diagnosis rendered before the pathological aggregation of α-Syn. The gene discussed is SERPINE1; the disease is Parkinson disease.