To definitively determine if the anti-tumor activity observed in Kynu-/- mice was a direct consequence of QAs role in immune suppression, CD8 + T cell depletion studies were performed, which completely mitigated the anti-tumor activity observed in Kynu-/- mice, providing further support for QAs immune suppressive role in GBM and its therapeutic potential. The gene discussed is CD8A; the disease is neoplasm.