Similarly, it was found that the high-glucose levels increased the TRAF2 expression and decreased the OTUD7B expression (Fig. 4A), meaning hyperglycemia could also promote mTORC1 assembly over mTORC2 assembly through stimulating the GβL-ubiquitination and, consequently, its preferable incorporation into mTORC1. The gene discussed is MLST8; the disease is Hyperglycemia.