MAPKAP1 and Hyperglycemia: The results also revealed increased p-Rictor (Ser1591) and p-Sin1 (Thr86) levels but decreased p-Akt(Ser473) and p-Raptor (Ser863) levels in the high-glucose-treated cells (Fig. 4B), suggesting that hyperglycemia promotes mTORC1 formation over mTORC2 formation.