Consistent with the results mentioned above (Figure 4B), Rig-I knockdown greatly enhanced the capacity of OT-I CD8+ T cells to restrict MC38-OVA tumor growth (Figure 5E), and this phenomenon was accompanied with greatly increased accumulation of the antigen-specific CD8+ T cell (Figure 5F) and elevated expression of CD107a and IFN-γ (Figure 5G). The gene discussed is IFNG; the disease is neoplasm.