RIGI and neoplasm: Suggestive of a crucial involvement of CD8+ T cells in restraining tumor growth within Rig-I–/– mice, antibody-mediated depletion of CD8+ T cells,but not CD4+ T or NK1.1+ cells, eliminated the restriction on tumor growth specifically by the Rig-I–/– host, while NK cell depletion promoted tumor growth similarly in Rig-I+/+ and Rig-I–/– mice (Figure 1, H and I, and Supplemental Figure 1, H and I).