Increased infiltration of Rig-I–/– CD8+ T cells compared with Rig-I+/+ CD8+ T cells was also found in inoculated B16F10 tumors (Supplemental Figure 3H), and less cell death but increased IFN-γ levels of tumor-infiltrating Rig-I–/– CD8+ T cells than WT CD8+ T cells were detected by flow cytometry (Supplemental Figure 3, I and J). This evidence concerns the gene RIGI and neoplasm.