PRF1 and neoplasm: By examining the levels of effector molecules (CD69, CD107a, GZMA, IFN-γ, TNF-α, GZMB, and Perforin-1), we also noticed that the tumor-infiltrating CD8+ T cell effector response was significantly enhanced by Rig-I deficiency (Figure 2, E–I, and Supplemental Figure 2A).