On the other hand, although PD-1 and TIM-3 expression increased with human CD8+ T cell activation, RIG-I deficiency reduced TIM-3 elevation (Supplemental Figure 8D); these inhibitory markers seemed not to change when RIG-I expression varied in tumor-infiltrating CD8+ T cells of tumor samples (Supplemental Figure 8, E and F). The gene discussed is HAVCR2; the disease is neoplasm.