Moreover, flow cytometric analysis and IHC showed increased infiltration of Rig-I–/– CD8+ T cells compared with Rig-I+/+ CD8+ T cells in the tumor (Figure 4C and Supplemental Figure 3B); as expected, the tumor-infiltrating Rig-I–/– CD8+ T cells exhibited less cell death but increased IFN-γ and CD107a levels than the tumor-infiltrating WT CD8+ T cells (Figure 4, D and E, and Supplemental Figure 3C). The gene discussed is RIGI; the disease is neoplasm.