DSC2 and neoplasm: Functionally, the extent of DSC2 expression in tumour cells directly impacts their capacity to aggregate and, in turn, influences their chemosensitivity, as shown in in vitro analyses after DSC2 up-regulation and DSC2 silencing in the TNBC cell line MDA-MB-231 and its brain-seeking subline MDA-MB-231-BR, respectively.