In line with a previous study on brain metastasis samples from patients with different tumour entities, which identified DSC2 as a potential marker for brain metastasis development [27], we found that high DSC2 mRNA expression significantly correlated with an increased risk for cerebral and lung metastases, although for the first localization, this trend could not be validated at a protein level. The gene discussed is DSC2; the disease is neoplasm.