Fetuin-A and fetuin-B clustered to CF piglet fraction 1–4 but are considered to be negative acute phase proteins as fetuin-A decreased in patients suffering from systemic inflammation due to bacterial infections, as opposed to alpha-1 antitrypsin and orosomucoid 1, which were upregulated in these patients [44] and fetuin-B mRNA was decreased in inflamed rats [45]. The gene discussed is ORM1; the disease is bacterial infectious disease.