Zubkiewicz-Kucharska A et al. reported a significant reduction in sklotho levels in children with type 1 diabetes, associated with HbA1c and HDL cholesterol, but not with adhesion molecule concentration and duration of disease, and the level of HbA1c was inversely associated with Soluble Klotho, suggesting a possible involvement in the development of chronic diabetic complications [16]. This evidence concerns the gene KL and type 1 diabetes mellitus.