Seven enriched KEGG pathways were correlated with the activity of Lactobacillus in the ER-negative group (p < 0.05), including “renal cell carcinoma” (CDC42, CRKL, PRCC), “viral carcinogenesis” (LTBR, CCND1, HIST2H2BE, CDC42, HIST2H2BF) and 94 GO terms were correlated with the activity of Lactobacillus in this group (p < 0.05) as presented in Supplementary file 6 A-B [22]. The gene discussed is H2BC18; the disease is hereditary clear cell renal cell carcinoma.