Baseline global cognitive function, hyposmia, rapid eye movement (REM) sleep behavior disorder (RBD), dysautonomia, apolipoprotein (APO) E status, β-glucocerebrosidase gene (GBA) status, and dopamine deficit on dopamine transporter (DAT)-imaging have all been suggested as predictors of MCI or dementia in patients with PD (Hu et al., 2014; Mata et al., 2014; Liu et al., 2017; Schrag et al., 2017; Leta et al., 2021; Barrio et al., 2022; Dijkstra et al., 2022). This evidence concerns the gene GBA1 and Parkinson disease.