In univariate analysis, the age of onset, sex, current diagnosis of hypertension, baseline MoCA scores, UPSIT scores, SCOPA-AUT gastrointestinal domain scores, RBDSQ-q6 scores, MDS-UPDRS III scores, the Hoehn and Yahr stage, and APOE status were associated with CI (Table 2). The gene discussed is APOE; the disease is hypertensive disorder.