Exposure to IS increased AD-like behaviors in the EPMT, LDTT, TST, and FST and IL-6 expression and NF-κB+Iba1+ cell number in the hippocampus and hypothalamus, whereas BDNF+NeuN+ cell number in the hippocampus and serotonin and dopamine levels in the hypothalamus decreased (Fig. 1). Here, IL6 is linked to Alzheimer disease.