NFKB1 and colitis: Oral gavage of Rd or CK at doses of 1 mg/kg and 5 mg/kg also suppressed IS-induced colitis: their treatments alleviated colon shortening and down-regulated colonic myeloperoxidase, TNF-α, and IL-6 expression, and NF-κB+CD11c+ cell number (Fig. 4).