RYR1 and Alzheimer disease: Several research groups have pointed to a role for RyR in the dysregulation of Ca2+ signaling, as neuronal expression of RyR has been increased in various AD mouse models and cell lines (Chan et al., 2000, Stutzmann et al., 2006, Bruno et al., 2011, Chakroborty et al., 2012, Bussiere et al., 2017).