Increased INFλ levels lead to LCN-2 upregulation and neutrophil activation; inhibition of this INFλ inflammatory signal, through AKT2 inhibition, leads to decreased LCN-2-mediated neutrophil infiltration, which may provide a novel therapeutic approach to early dry AMD (Ghosh et al., 2019). The gene discussed is LCN2; the disease is dry age related macular degeneration.