We and others have identified triose-phosphate isomerase (TPI) as a target for NO-mediated post-translational modifications in neurodegenerative diseases, rendering the enzyme inactive and linking to enhanced glycation signalling (Guix et al., 2009; Tajes et al., 2014a,b; Bourgognon et al., 2021). Here, TPI1 is linked to neurodegenerative disease.