Mn2+ can induce the production of IFN-I by activating cGAS-STING pathway to promote the maturation and activation of tumor-infiltrating macrophages and DCs, and enhance the presentation of tumor-specific antigens (126), which is a key step in activating CD8+T cells and increasing the proportion of memory CD8+T cells (128, 129). Here, CD8A is linked to neoplasm.