The cGAS-STING pathway can also be activated by tumor-derived dsDNA to induce IFN-I, which can promote the maturation/activation of tumor-infiltrating dendritic cell (DCs) or macrophages and enhance the presentation of tumor-specific antigens to activate CD8+T cells and NK cells for tumor immune responses (41, 42). The gene discussed is CGAS; the disease is neoplasm.